Thursday, June 7, 2012

Dental science: Oral observatory

http://www.nature.com/naturejobs/science/articles/10.1038/nj7401-147a?WT.ec_id=NATUREjobs-20120607
Studying the mouth, including the diagnostic potential of saliva, is offering opportunities to explore overall health.
In 2010, Michael Lau received an e-mail from a recruiter seeking candidates for a position at the University of California, Los Angeles (UCLA). Would he be interested, the recruiter asked, in applying for a postdoc related to salivary diagnostics? Lau, who was finishing his biochemistry and molecular biology PhD at the University of California, Riverside, and considering his career options, was intrigued and surprised. “I had no idea that you could actually detect systemic diseases, and oral diseases, using saliva,” says Lau.

The opening was in the laboratory of David Wong, associate dean of research at the UCLA School of Dentistry. Wong's group had found in saliva potential biomarkers for oral cancer and the autoimmune disease Sjögren's syndrome, and was searching for others. With his interest piqued, and keen on the potential for practical diagnostic use, Lau successfully applied for the post.

http://dx.doi.org/10.1371/journal.pone.0033037

The National Institute of Dental and Craniofacial Research (NIDCR) in Bethesda, Maryland, invested US$65.6 million into salivary diagnostics research between 2002 and 2011, and the human salivary proteome — an inventory of proteins secreted by salivary glands — was published in 2008 (P. Denny et al. J. Proteome Res. 7, 1994–2006; 2008).

Daniel Malamud says now is the perfect time to become a oral-diagnostics researcher.

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