Monogenic genetic disorders occur as a direct consequence of a single gene being defective. Such disorders are inherited (passed on from one generation to another) in a simple pattern according to Mendel's Laws. As such, these disorders are often referred to as Mendelian disorders. However, many disorders are not inherited in this pattern. These include disorders due to more than one gene (polygenic disorders), those caused by mutations in non-nuclear mitochondrial genes (such as Leber's atrophy) and nucleotide repeat disorders (such as myotonic dystrophy).
http://www.geneticalliance.org.uk/education2.htm
No comments:
Post a Comment