http://en.wikipedia.org/wiki/FOXP2
The FOXP2 protein contains a forkhead-box DNA-binding domain, making it a member of the FOX group of transcription factors, involved in regulation of gene expression. In addition to this characteristic forkhead-box domain, the protein contains a polyglutamine tract, a zinc finger and a leucine zipper.
In humans, mutations of FOXP2 cause a severe speech and language disorder. One particular target that is directly downregulated by FOXP2 in human neurons is the CNTNAP2 gene, a member of the neurexin family; variants in this target gene have been associated with common forms of language impairment.
FOXP2 directly regulates a large number of downstream target genes
http://www.medicalnewstoday.com/articles/230758.php
No comments:
Post a Comment