http://www.nature.com/nmeth/journal/v9/n11/full/nmeth.2236.html?WT.ec_id=NMETH-201211
Two complete normal brains from adult male donors were first imaged by
magnetic resonance imaging, then cut into sections, analyzed using
histological techniques and finally reduced to 900 samples
Despite the fact that the neocortex is composed of over 15 billion
neurons, the genetic signature of its different regions proved to be
relatively homogeneous.
The group found that genetic variation across the different neocortical
areas followed a graded pattern: the closer two neighboring regions
were, the more similar their transcriptomes.
calcium binding protein CALB1, with a profile that was unique to humans
et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature 489, 391–399 (2012).
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