Published studies examining alpha-synuclein expression in Parkinson's Disease

The ups and downs of alpha-synuclein mRNA expression
http://www.ncbi.nlm.nih.gov/pubmed/17094104

- selecting of appropriate "housekeeping" gene for expression normalization is very important
- used four housekeeping genes GAPDH, synaptophysin, HPRT, YWHAZ

brain regions with varying levels of alpha-synuclein pathology:
- occipital lobe (resistant)
- putamen (intermediate)
- amygdala (vulnerable)
- substantia nigra (highly vulnerable)