Boosting Signal-to-Noise in Complex Biology: Prior Knowledge Is Power

Trey Ideker, Janusz Dutkowski, and Leroy Hood, “Boosting Signal-to-Noise in Complex Biology: Prior Knowledge Is Power,” Cell 144, no. 6 (March 2011): 860-863.

http://www.cell.com/abstract/S0092-8674(11)00244-3

- filter
- integrators: combine many weak signals to increase statistical power

Examples
- Roach et al., 2010 - Familial SNV study found 3 candidate genes for Miller syndrome
- protein signaling network of kinases and phosphotases: McGary et al., 2010 - same network across species control diff. phenotypes and diff. network show similar phenotype (Erwin and Davidson 2009)