Wednesday, February 15, 2012

The ups and downs of alpha-synuclein mRNA expression.

Neystat et al. 1999 iPD: 9/con.: 8 Substantia nigra/frontal cortex RPA VMAT2 Diminished α-synuclein mRNA levels in the substantia nigra of PD cases, no changes in the cortex

Dachsel et al. 2006 iPD: 9/ con.: 5 Amygdala/occipital lobe/striatum/ RT-PCR Synaptop./YWHAZ/HPRT/GAPDH Strongly reduced α-synuclein mRNA levels in PD substantia nigra, moderate but significant decrease in PD putamen and occipital lobe, no change in amygdala

Kingsbury et al. 2004 Cortex: iPD: 8/ con.: 4 midbrain: iPD: 7/ con.: 4 Cortex/midbrain Semiquant. in situ hybridization α-synuclein mRNA expression significantly reduced in melanized neurons in substantia nigra and frontal cortex in PD

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