http://www.nature.com/news/cancer-causing-mutations-yield-their-secrets-1.10029?WT.ec_id=NEWS-20120221
The mystery of how mutations in a gene called isocitrate dehydrogenase 1 (IDH1) cause brain cancer and leukaemia is beginning to be unravelled. Researchers have discovered that the mutations cause the production of an enzyme that can reconfigure on–off switches across the genome and stop cells from differentiating.
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