Tuesday, February 21, 2012

Nanopore genome sequencer makes its debut

http://www.nature.com/news/nanopore-genome-sequencer-makes-its-debut-1.10051?WT.ec_id=NEWS-20120221

Technology that its parent company says will sequence a human genome in just 15 minutes opened its first data run to scrutiny today.

Oxford Nanopore Technologies, based in Oxford, UK, revealed the initial results from its GridION system at the Advances in Genome Biology and Technology meeting in Marco Island, Florida. The firm expects to start selling its new machine in the second half of this year and also plans to launch the world’s first miniaturized, disposable sequencer — the MinION — which will retail for less than US$900.

The potential advantages of the nanopore system are that it could deliver real-time seqeuncing of single molecules at low cost, and should not damage the DNA, so in theory the same molecule can be reanalysed, said Brown.

The technology has a 4% error rate, meaning that 4% of the bases are read incorrectly, but Brown says that the company is working to cut this down to 0.1– 1% by the time the system launches, which would make it more competitive with current systems.

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