ToppGene Suite - gene list enrichment analysis and candidate gene prioritization

http://toppgene.cchmc.org/


* ToppFun: Transcriptome, ontology, phenotype, proteome, and pharmacome annotations based gene list functional enrichment analysis

Detect functional enrichment of your gene list based on Transcriptome, Proteome, Regulome (TFBS and miRNA), Ontologies (GO, Pathway), Phenotype (human disease and mouse phenotype), Pharmacome (Drug-Gene associations), literature co-citation, and other features.

* ToppGene: Candidate gene prioritization

Prioritize or rank candidate genes based on functional similarity to training gene list.

* ToppNet: Relative importance of candidate genes in networks

Prioritize or rank candidate genes based on topological features in protein-protein interaction network.

* ToppGenet: Prioritization of neighboring genes in protein-protein interaction network

Identify and prioritize the neighboring genes of the seeds in protein-protein interaction network based on functional similarity to the "seed" list (ToppGene) or topological features in protein-protein interaction network (ToppNet).