miRNA / mRNA regulation
Talk by Phil Sharp at the 2010 Genome Sciences Centre Forum
- seed region (2-7nt) near the 5' end of the miRNA
- mIR-290-295, mIR-21, let-7
- fibroblast (extra-cellular matrices, ECM, connective tissue) converted to iPS (Induced pluripotent stem cell) via Oct4, Sox2, Nanog, Tck3 (http://en.wikipedia.org/wiki/Induced_pluripotent_stem_cell)
- Hanahan and Weinberg 2000, The hallmarks of cancer.
- loss in miRNA leads to increase in tumor formation
- there's a threshold when miRNA stops working ...
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Talk by Angie-Brooks Wilson (G3, Genetics, Genomics, Gerentology)
- GWAS
- super seniors, healthy >85 year-olds
- ~20% genetics
- APOE4 - Alzheimer, heart disease (rs429358 SNP)
- BECN1 - lifespan in C. elegans (rs10512488 SNP)
- increase in cytokines -> increase in inflammation, tendency to age?
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