microRNAs: Master Regulators as Potential Therapeutics in Cancer
Michela Garofalo and Carlo M. Croce
Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive
Cancer Center, Ohio State University, Columbus, Ohio 43210;
email: michela.garofalo@osumc.edu, carlo.croce@osumc.edu
http://www.annualreviews.org/doi/abs/10.1146/annurev-pharmtox-010510-100517
Cell. 2009 Jan 23;136(2):215-33.
MicroRNAs: target recognition and regulatory functions.
Bartel DP.
http://www.ncbi.nlm.nih.gov/pubmed/19167326
http://download.cell.com/pdf/PIIS0092867409000087.pdf
Many miRNAs have been shown to function as oncogenes in the majority of cancers profiled to date (Table 1). miR-155 was one of the first described (30).
miR-155, miR-21, miR-221&222, miR-106b-93-25 cluster, miR-17-92 cluster
The tumor suppressor function of miR-15a/16-1 has also been addressed
in vivo.
The most promising therapeutic techniques tested to date are
(a) miRNA mimics and (b) anti-miRNA oligonucleotides (AMOs).
http://www.youtube.com/watch?v=oANi7PRqalM
TAM: A method for enrichment and depletion analysis of a microRNA category in a list of microRNAs
Ming Lu1 Bing Shi1,2 Juan Wang1 Qun Cao1 Qinghua Cui1
http://www.biomedcentral.com/1471-2105/11/419
TargetSpy: a supervised machine learning approach for microRNA target prediction
Martin Sturm1 Michael Hackenberg2 David Langenberger3,4 Dmitrij Frishman1,4
http://www.biomedcentral.com/1471-2105/11/292
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