Scott J Russo, James W Murrough, Ming-Hu Han, Dennis S Charney & Eric J Nestler
Nature Neuroscience 15, 1475–1484 (2012) doi:10.1038/nn.3234
Humans exhibit a remarkable degree of resilience in the face
of extreme stress, with most resisting the development of
neuropsychiatric disorders. Over the past 5 years, there has been
increasing interest in the active, adaptive coping mechanisms of
resilience; however, in humans, most published work focuses on
correlative neuroendocrine markers that are associated with a resilient
phenotype. In this review, we highlight a growing literature in rodents
that is starting to complement the human work by identifying the active
behavioral, neural, molecular and hormonal basis of resilience. The
therapeutic implications of these findings are important and can pave
the way for an innovative approach to drug development for a range of
stress-related syndromes.
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