... so basically, use laser tweezers to isolate an unculturable bacteria (eg. SFB segmented filamentous bacteria, found in the lining of intestines) so that you can amplify them and sequence
.... in a microfluidic environment, you can minimize the contamination that comes with amplification reagents due to smaller volume in chambers and it's a closed environment so contamination from air can't come in
Table of Contents
00:00 - Introduction
01:33 - Talk begins
03:26 - What is microfluidics?
09:24 - Microelectronics: a recent micro-tech revolution
13:12 - The complexity of biological systems
17:50 - How to unravel biological mysteries
21:24 - Is there a Moore's law for experimental biology?
23:55 - Methods and possibilities of modern microfluidics
30:23 - Studying single cells with microfluidics
34:33 - Moving cells with laser tweezers
35:18 - Preventing contamination using microfluidics
40:38 - Intestinal bacteria and their DNA
44:55 - A new revolution in life science is beginning...
46:30 - Acknowledgements
47:10 - Q&A
Miniaturized lab-on-a-chip methods are being deployed as labor-saving devices in biological research, through the advent of a suite of microfluidics technologies. Microfluidics enables large-scale studies that provide the means to better understand, prevent, and treat human disease. In his 2012 Midsummer Nights' Science lecture, Paul Blainey discusses the promise of using microfluidics to transform our industrial infrastructure to operate more efficiently, while protecting the natural environment.
Find out more about Paul Blainey's work at the Broad Institute and about our public lecture series and other educational opportunities:
-Blainey lab page (http://www.broadinstitute.org/node/4165/)
-Broad news story (http://www.broadinstitute.org/news/3068)
-Education (http://www.broadinstitute.org/node/635/)
-Broad Institute Midsummer Nights' Science series (http://www.broadinstitute.org/midsummer)
00:00 - Introduction
01:33 - Talk begins
03:26 - What is microfluidics?
09:24 - Microelectronics: a recent micro-tech revolution
13:12 - The complexity of biological systems
17:50 - How to unravel biological mysteries
21:24 - Is there a Moore's law for experimental biology?
23:55 - Methods and possibilities of modern microfluidics
30:23 - Studying single cells with microfluidics
34:33 - Moving cells with laser tweezers
35:18 - Preventing contamination using microfluidics
40:38 - Intestinal bacteria and their DNA
44:55 - A new revolution in life science is beginning...
46:30 - Acknowledgements
47:10 - Q&A
Miniaturized lab-on-a-chip methods are being deployed as labor-saving devices in biological research, through the advent of a suite of microfluidics technologies. Microfluidics enables large-scale studies that provide the means to better understand, prevent, and treat human disease. In his 2012 Midsummer Nights' Science lecture, Paul Blainey discusses the promise of using microfluidics to transform our industrial infrastructure to operate more efficiently, while protecting the natural environment.
Find out more about Paul Blainey's work at the Broad Institute and about our public lecture series and other educational opportunities:
-Blainey lab page (http://www.broadinstitute.org/node/4165/)
-Broad news story (http://www.broadinstitute.org/news/3068)
-Education (http://www.broadinstitute.org/node/635/)
-Broad Institute Midsummer Nights' Science series (http://www.broadinstitute.org/midsummer)
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