Biclustering algorithms

Iterative Signature Algorithm (ISA)

The intuition is that the genes in a bicluster are co-regulated and, thus,
for each sample the average gene expression over all the biclsuter’s genes should be surprising
(unusually high or low) and for each gene the average gene expression over all biclusters samples
should be surprising. This intuition is formalized using a simple linear model for gene expression
assuming normally distributed expression levels for each gene or sample

http://cs.fit.edu/~dmitra/Compbio/Resources/BiclusterRevw-Tanay2004.pdf

http://cran.r-project.org/web/packages/isa2/isa2.pdf