Genotype vs Haplotype

Genotype
- single locus
- eg. AA, Aa, aa

Haplotype
- an ordered list of alleles of multiple linked loci on a single chromosome
- A way of denoting the collective genotype of a number of closely linked loci on a chromosome.
- multiple locus
- eg. ABC, ABc

Haploytpe Phasing
www.pnas.org/content/108/1/12.abstract
- Determining from which parent (mom or dad) haplotype came from
- HapMap obtained this info from 30 mother-father-child trios
- Other ways include SNP array profiling from chromosome microdissection
- To determine the haplotypes from genotypes containing tightly linked SNPs from a set of n individuals
- Determining Which SNPs are Inherited Together http://www.chromosomechronicles.com/2009/09/08/phasing-determining-which-snps-are-inherited-together/


www.sph.umich.edu/~qin/lect1.ppt
http://www.bio.net/mm/gen-link/1998-October/001554.html
http://www.ornl.gov/sci/techresources/Human_Genome/glossary/glossary.shtml#H