A common approach to understanding the genetic basis of complex traits is through identification of associated quantitative trait loci (QTL). Fine mapping QTLs requires several generations of backcrosses and analysis of large populations, which is time-consuming and costly effort.
http://www.biomedcentral.com/1471-2105/11/525/abstract
http://www.biomedcentral.com/1471-2105/11/526/abstract
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