Thursday, October 28, 2010

ncRNA, probe, GWAS

A method for automatically extracting infectious disease-related primers and probes from the literature
http://www.biomedcentral.com/1471-2105/11/410

Classification of ncRNAs using position and size information in deep
sequencing data
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935403/?tool=pubmed

Forward-time simulation of realistic samples for genome-wide association studies
http://www.biomedcentral.com/1471-2105/11/442
Genetic drift or allelic drift is the change in the frequency of a gene variant (allele) in a population due to random sampling.  The alleles in the offspring are a sample of those in the parents, and chance has a role in determining whether a given individual survives and reproduces. vs (natural selection)

In population genetics, linkage disequilibrium is the non-random association of alleles at two or more loci, not necessarily on the same chromosome. It is not the same as linkage, which describes the association of two or more loci on a chromosome with limited recombination between them. Linkage disequilibrium describes a situation in which some combinations of alleles or genetic markers occur more or less frequently in a population than would be expected from a random formation of haplotypes from alleles based on their frequencies. Non-random associations between polymorphisms at different loci are measured by the degree of linkage disequilibrium (LD). Numerically, it is the difference between observed and expected (assuming random distributions) allelic frequencies.

Detection and characterization of novel sequence insertions using paired-end next-generation sequencing.
http://bioinformatics.oxfordjournals.org/content/26/10/1277.full

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