Thursday, December 2, 2010

CGH, Chromosomal Microarray Analysis (CMA), Copy number variation (CNV)

Comparative genomic hybridization (CGH) or Chromosomal Microarray Analysis (CMA) is a molecular-cytogenetic method for the analysis of copy number changes (gains/losses) in the DNA content of a given subject's DNA and often in tumor cells.

CGH will detect only unbalanced chromosomal changes. Structural chromosome aberrations such as balanced reciprocal translocations or inversions cannot be detected, as they do not change the copy number.

http://en.wikipedia.org/wiki/Comparative_genomic_hybridization

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