Thursday, June 9, 2011

Statistics and Genetics

http://pngu.mgh.harvard.edu/~purcell/plink/

PLINK is a free, open-source whole genome association analysis toolset, designed to perform a range of basic, large-scale analyses in a computationally efficient manner.

The focus of PLINK is purely on analysis of genotype/phenotype data, so there is no support for steps prior to this (e.g. study design and planning, generating genotype or CNV calls from raw data). Through integration with gPLINK and Haploview, there is some support for the subsequent visualization, annotation and storage of results.

Haplotype analysis in R

Haploview is fully compatible with data dumps from the HapMap project and the Perlegen Genotype Browser. It can analyze thousands of SNPs (tens of thousands in command line mode) in thousands of individuals.
http://www.broadinstitute.org/scientific-community/science/programs/medical-and-population-genetics/haploview/haploview

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