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Genome Biology 2011, 12:408Next-generation human genetics
Exome and genome sequencing are reshaping the landscape of human genetics; Jay Shendure discusses the lessons learnt and opportunities opened
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Genome Biology 2011, 12:407Exome issue editorial
Special Issues Editor, Hannah Stower, introduces Genome Biology's issue on exome sequencing
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Genome Biology 2011, 12:228Unlocking Mendelian disease using exome sequencing
In the past 2 years, exome sequencing has provided significant new insights into the causes of both Mendelian and sporadic genetic diseases
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Genome Biology 2011, 12:227Exome sequencing
Many computational and statistical methods are now available to narrow down causal variants in exome sequencing data, for both Mendelian and complex diseases
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Genome Biology 2011, 12:128Exome sequencing: the expert view
Three leaders in the field of exome sequencing discuss why the approach is so popular and how it is contributing to genomics
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Genome Biology 2011, 12:127Population exomics and human evolution
Exome sequencing is poised to yield substantial insights into human genetic variation and evolutionary history, but there are significant challenges to overcome before this becomes a reality
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Genome Biology 2011, 12:R89Hereditary hearing loss genes
Targeted capture and sequencing of genomic DNA from subjects with inherited hearing loss offers an effective screen for mutations
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Genome Biology 2011, 12:R88Wheat exon capture
Capture tools for 3.5 Mb exon regions of allotetraploid wheat are developed and applied to identify coding differences in wild and cultivated wheat
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Genome Biology 2011, 12:R86Mouse exome capture
In solution capture reagents are developed for the mouse exome and demonstrated in multiple inbred strains and novel mutant strains
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Genome Biology 2011, 12:R85Exome linkage analysis
A method for performing linkage analysis from exome sequencing variant data is presented
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Genome Biology 2011, 12:R84Rare coding variants
The 1000 Genomes Project presents exome sequence data for 1000 genes from 700 individuals, better defining low frequency variants
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Genome Biology 2011, 12:125The cost of sequencing
The sharp decrease in the cost of 'data generation' has not been matched by a comparable decrease in the cost of the computational infrastructure required to mine the data
Just a collection of some random cool stuff. PS. Almost 99% of the contents here are not mine and I don't take credit for them, I reference and copy part of the interesting sections.
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